Thyroid Failure – hypothyroidism

What happens when the thyroid fails? How does the body react to less thyroid hormone in the circulation? Below is an illustration of a plot of the thyroid as the basis for an explanation of what is released from the thyroid.

These results suggest the existence of a functional TSH-T3 shunt that is mainly mediated via the thyroid. (

DT: Damping constant (EC50) of TSH at the Thyroid.

GT3: The secretory capacity of the thyroid

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