Brokken–Wiersinga–Prummel loop

Description of the Brokken–Wiersinga–Prummel loop:

Normal values

The structural parameters for the Brokken–Wiersinga–Prummel loop. Standard value for GT. No other parameters are changed.

Hypothyroid

The structural parameters for the Brokken–Wiersinga–Prummel loop. Value for GT: 1E-13. No other parameters are changed.

Thyrotoxicosis

The structural parameters for the Brokken–Wiersinga–Prummel loop. Value for GT: 2E-10. No other parameters are changed.

Note the differences in the patterns, particularly varying effects of ultrashort-loop feedback parameters SS and DS with respect to different functional states (GT) of the overall feedback control system (1.). NOTE NOT EXACT NUMBERS!

TrendHypothyroidStandardThyrotoxicosis
secretory capacity of the thyroid glandGT\– 8,5 -> + 12– 7 -> + 9,5-6 -> + 8
secretory capacity of the pituitary glandGHU– 10,5 -> + 9,3– 9 -> + 8– 10,3 -> + 9
damping constant of TRH (anterior pituitary)DHU– 7,8 -> + 10-6,6 -> 8,2– 7,5 -> + 9,8
brake constant of Brokken–Wiersinga–Prummel feedback loopSS\– 8 -> + 11– 6 -> 7,8– 4 -> + 4,5
damping constant of TSH (anterior pituitary)DS\– 8,2 -> 7,8– 7 -> 6– 5 -> + 3,9
Not consistent patterns – what are the explanations?
  1. Midgley JEM,Hoermann R, Larisch R,et al.J Clin Pathol Published Online First: [May 12, 2016] doi:10.1136/jclinpath-2012-201213