DT

What happens when the thyroid fails? How does the body react to less thyroid hormone in the circulation? Below is an illustration of a plot of the thyroid as the basis for an explanation of what is released from the thyroid.

These results suggest the existence of a functional TSH-T3 shunt that is mainly mediated via the thyroid. (https://sourceforge.net/p/simthyr/discussion/research/thread/ad36b99a/)

DT: Damping constant (EC50) of TSH at the Thyroid.

GT3: The secretory capacity of the thyroid

DT: Damping constant (EC50) of TSH at the Thyroid.

TABLE 11	Decrease DT ( /10 )	STANDARD FIGURES	Increase DT (x10)
TRH	2500	2500	2500
TSH	1.2151	1,8	3.5831
TT4	250.1930	121,94	35.3682
FT4	36.2546	17,67	5.1251
TT3	6.5979	3,21	0.9328
FT3	10.9781	5,35	1.5520
cT3	23562.9892	11693,7490	3434.1110

When the dampening constant is increased we see these changes in the thyroid hormones. Visualised below:

The standard figures visualised:

When the dampening constant is decreased we see these changes in the thyroid hormones. Visualised below: