One-Way Sensitivity Analysis – GT

GD 1: Sum activity of peripheral type 1 deiodinase (D1).
As can be seen, TSH and fT4 are horizontal and fT3 levels increase with increased GD1 level. Reflecting that increase and decrease of GD1 only affects T3/fT3 values. The green area is the reference range for GD

GD1 Decreased
GD1 Increased
GD1 Decreased
GD Increased
BetaS Decreased
BetaS Standard
BetaS Increased
Beta S2 Decreased
Beta S2 Standard
Beta S2 Increased
TBG Decreased
TBG Standard
TBG Increased
TBPA Decreased
TBPA Standard
TBPA Increased
DH Decreased
DH Standard
DH Increased
DT Decreased
DT Standard

DT Increased
GD2 Decreased
GD2 Standard
GD2 Increased
GR Decreased
GR Standard
GR Increased
LS Decreased
LS Standard
LS Increased
SS Decreased
SS Standard
SS Increased
Beta31 Decreased
Beta31 Standard
Beta31 Increased
DR Decreased
DR Standard
DR Increased
DS Decreased
DS Standard
DS Increased
GH Decreased
GH Standard
GH Increased
KM2 Decreased
KM2 Standard
KM2 Increased
BetaT Decreased
BetaT Standard
BetaT Increased
GT Decreased
GT Standard
GT Increased
KM1 Decreased
KM1 Standard
KM1 Increased
Beta31 Decreased
Beta31 Standard
Beta31 Increased
Beta32 Decreased
Beta32 Standard
Beta32 Increased


In the euthyroid state, others and we have observed a considerable interindividual variability in FT4, TSH and their regulatory set points.15 39 40

Possible molecular mechanisms may include either different individual concentrations and affinities of TRs, variations in the distribution of iodothyronine transporters or a polymorphism in the type 2 deiodinase, which in the presence of a homozygous allele weakens the negative feedback of FT4 on TSH in humans.40 41

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